5330 Med. Sci. I
3695 Med. Sci. II (North Lecture Hall)
5330 Medical Science I
5623 Med. Sci. II (Wheeler Seminar Room)
The intestinal microbiota encode millions of genes that represent unique pharmaceutical targets for human diseases from neurological disorders to drug toxicity. We are interested in the role the intestinal microbiota play in reactivating compounds that have been inactivated through glucuronidation in the liver. In particular, the chemotherapy drug CPT-11, or irinotecan, is inactivated by UGTs in the liver and then reactivated by bacterial b-glucuronidase (GUS) enzymes in the large intestine resulting in dose-limiting diarrhea.
BSRB Seminar Rooms A, B, and C
Great Lakes North, Palmer Commons Building
We coexist with a vast number of microbes—our microbiota—that live in and on our bodies, and play an important role in human physiology and diseases. Propelled by metagenomics and next-generation DNA sequencing technologies, many scientific advances have been made through the work of large-scale, consortium-driven metagenomic projects. Despite these advances, there are still many fundamental questions regarding the dynamics and control of microbiota to be addressed.
3697 WEST LECTURE HALL, MED SCI 2