The goal of this workshop is to discuss whether microbial pathogens may represent a causal component of Alzheimer’s disease, review knowledge gaps, and establish scientific priorities to address these gaps.

DAY ONE

10:00 a.m.
Welcome Remarks
Eliezer Masliah (NIA)

10:10 a.m.
Workshop Objectives
NIA DN Staff

Keynote

10:20 - 10:55 a.m.
The Antimicrobial Protection Hypothesis of Alzheimer’s Disease
Rudolph Tanzi
(Harvard University)

Break– 5 min

Session I: Herpes simplex and Alzheimer’s Disease – the epidemiological perspective
Session Chair:  Steven Jacobson

11:00 a.m.
Herpes virus infections, antiviral treatment and Alzheimer's disease
Hugo Lövheim
(Umeå University, Sweden)

11:15 a.m.
Association of herpesvirus diagnosis, anti-herpesviral treatment and herpesvirus vaccination with dementia
Christian Schnier
(University of Edinburgh, UK)

11:30 a.m.
Interrogating the brain microbiome in Alzheimer’s disease: Challenges and opportunities
Benjamin Readhead
(Arizona State University)
 

11:45 a.m.
Human Herpesvirus 6 detection in Alzheimer's disease cases and controls across multiple cohorts
Steven Jacobson
(NINDS IRP, NIH)

12 – 12:30 pm
Moderated Discussion
Moderator: Steven Jacobson
(NINDS IRP, NIH)

Lunch Break – 30 min

Session II: Herpes Viruses and Alzheimer’s Disease -The Debate Continues
Session Chair: Maria Nagel

1:00 p.m.
 
Amyloid beta and HSV1: A model for examining infection and innate immunity in Alzheimer's Disease
William Eimer
(Harvard University)

1:15 p.m.
Testing the hypothesis on viral etiology of late onset Alzheimer's disease
Ilia Baskakov
(University of Maryland)

1:30 p.m.
Exposure to Infectious Agents and Cognitive Function: the Baltimore Epidemiologic Catchment Area Study Follow-Up
Adam Spira
(Johns Hopkins Bloomberg School of Public Health)

1:45 p.m.
The potential role of Bacteroides in Alzheimer’s disease
Laura Cox
(Harvard)

2:00 p.m.
Enterobacterial infections as drivers of tauopathies
Irene Salinas
(University of New Mexico)

2 – 2:30
 p.m.
Moderated Discussion
 
Moderator: Maria Nagel
(University of Colorado)

ADJOURN DAY ONE

 

DAY TWO

Session III: Pathogens and Alzheimer’s Disease - Is there evidence for causation?
Session Chair: Adam Spira

9:55 a.m.
Welcome to Day Two
NIA DN Staff

10:00 a.m.
Single-cell dissection of pathogen-associated changes in Alzheimer's Disease
Manolis Kellis
(MIT)

10:15 a.m.
Periodontal disease and cognitive aging in a multiethnic cohort: Findings from the Washington Heights-Inwood Columbia Aging Project (WHICAP) Ancillary Study of Oral Health
James Noble
(Columbia University)
 

10:30 a.m.
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
Stephen Dominy
(Cortexyme, Inc., 
San Francisco)
 

Break – 15 min

11:00 a.m.
Clearance of amyloid beta in Toxoplasma-infected murine models of Alzheimer’s disease
Melissa Lodoen
(UC Irvine)

11:15 a.m.
Microglia, genetics and pathogens in AD
Elisabeth Bradshaw
(Columbia University)

11:30 a.m.
Cerebrospinal fluid immunity in Alzheimer’s disease
David Gate
(Northwestern University)

11:45 -
12:15 a.m.
Moderated Discussion
 
Moderator: Adam Spira
(Johns Hopkins Bloomberg School of Public Health)

Lunch Break- 30 min

Session III (cont.): Pathogens and Alzheimer’s Disease - Is there evidence for causation?
Session Chair: Avindra Nath

12:45 p.m.
HIV/AIDS and Alzheimer’s Disease
Eliezer Masliah

1:00 p.m.
Virus and olfactory system interactions accelerate Alzheimer’s disease pathology
Maria Nagel
(University of Colorado)

1:15 p.m.
HHV6A and Alzheimer’s disease
Chris Proschel
(University of Rochester)

Break 15 min

1:45 p.m.
Effects of Chlamydia pneumoniae infection on the brain and retina in Alzheimer’s Disease
Timothy Crother and Maya Koronyo-Hamaoui
(Cedars-Sinai Medical Center)

2:00 p.m.
Polymicrobial “Lichenoid” Cerebritis in Alzheimer’s Disease and Preclinical Models
David Corry
(Baylor College of Medicine)

2:15 p.m.
Repurposing of existing vaccines for Alzheimer’s prevention
Svetlana Ukraintseva
(Duke University)

2:30 -3:00 pm
Moderated Discussion
 
Moderator: Avindra Nath
(NINDS, IRP)

Break 10 min

3:10 pm
Synthesis by Moderators
 

3:40 pm
Final discussion
Mack Mackiewicz

4:10 pm
Closing Remarks
Eliezer Masliah

MEETING ADJOURNS