Visualizing Bacterial Physiology at High Resolution using Single-Molecule Tracking and Lattice-Light Sheet Microscopy
Thursday, February 13, 2020 - 4:00pm to 5:30pm
Andreas Gahlmann, Ph.D.
Department of Chemistry
Department of Molecular Physiology & Biological Physics
Center for Cell and Membrane Physiology
University of Virginia
Our lab develops new imaging approaches for visualizing bacterial physiology in relevant contexts: We use live-cell single-molecule localization microscopy and lattice-light sheet microscopy to access 3D spatial and temporal information with high resolution. At molecular and cellular length scales, our research focuses on understanding how Gram-negative bacterial pathogens inject effector proteins into the cytosol of eukaryotic host cells using the Type 3 Secretion System (T3SS) â a 7 MDa multi-protein complex that spans two, and sometimes three cellular membranes.
Laura Mike, Ph.D.
My research focuses on targeting E. coli iron homeostasis using small molecules and natural products.
David Sherman, Ph.D.
secondary metabolism, natural products