March 29, 2017
9:00 am to 10:00 am

5623 Med. Sci. II (Wheeler Seminar Room)

Lindsay Caverly, M.D.
Assistant Professor
Department of Pediatrics University of Michigan Medical School
University of Michigan Medical School

Nontuberculous mycobacterial (NTM) pulmonary infections affect >85,000 people per year in the United States, with associated annual medical costs recently estimated at $815 million. Individuals with cystic fibrosis (CF) are at a 1,000-fold greater risk of NTM infection than the general population, and prevalence rates of NTM infection in CF are rising. Infection with NTM can result in progressive lung damage, lung function decline, and death for individuals with CF.

March 30, 2017
12:00 pm to 1:00 pm

5330 Med. Sci. I

Dana Philpott, Ph.D.
Associate professor, Immunology
University of Toronto
April 5, 2017
9:00 am to 10:00 am

5623 Med. Sci. II  (Wheeler Seminar Room)

Kei Sakamoto, M.D., Ph.D.
Research Fellow - Nunez Lab
Department of Pathology

Iron is an essential nutrient for multicellular organisms and nearly all microorganisms including pathogenic bacteria. In mammals, the majority of iron is found in erythrocytes where is bound to heme moieties in hemoglobin. Given the strict requirement for iron by practically all pathogenic bacteria, the host immune system has developed several strategies to limit iron availability to bacteria. However, the mechanisms by which the immune system limits the availability of heme, the major source of iron in the body, to restrict bacterial growth in vivo remain unclear.

April 12, 2017
9:00 am to 10:00 am

5623 Med. Sci. II (Wheeler Seminar Room)

Kaitlin Flynn, Ph.D.
Postdoctoral Fellow - Schloss Lab

Colorectal cancer (CRC) remains a leading cause of death worldwide. Tumors of the proximal (right) and distal (left) colon are morphologically and genetically distinct. Previous work from our group found that microbial dysbiosis is associated with the development of colorectal cancer tumors in studies of both mice and humans. Analysis of the fecal microbiota from healthy and CRC patients further revealed different microbial signatures associated with disease. In this study, we extended our observations of the fecal microbiome to analysis of the proximal and distal human colon.