5330 Med. Sci. I
5623 Med. Sci. II (Wheeler Seminar Room)
The gut microbiome can have numerous effects throughout the body. These effects are largely mediated through small molecules, such as the short chain fatty acids (SCFA) that are the end product of carbohydrate fermentation in the gut. Of the SCFA, butyrate is regarded as the most beneficial, serving as the primary energy source of colonocytes and exhibiting anti-inflammatory, anti-diabetic and anti-tumorigenic effects. Prebiotic intake can lead to increased butyrate levels and in particular the dietary fiber resistant starch is known to be highly butyrogenic.
Palmer Commons - Forum Hall
In the last ten years electron cryotomography has made it possible to visualize large macromolecular assemblies inside intact cells in a near-native, "frozen-hydrated" state in 3-D to a few nanometers resolution. Increasingly, atomic models of individual proteins and smaller complexes obtained by X-ray crystallography, NMR spectroscopy, or other methods can be fit into cryotomograms to reveal how the various pieces work together inside cells.