A post-doctoral position is available immediately in Dr. Ganjam Kalpana’s laboratory at the Albert Einstein College of Medicine to investigate host-virus interactions of HIV-1 and the mechanism of HIV persistence and latency. These studies are focused on the interaction between integrase and INI1/SMARCB1. Recent NMR structural studies and modeling of the IN-INI1 domain complex have revealed an unprecedented finding of RNA mimicry by the INI1/SMARCB1 protein domain (Nature Communications 2021) and have led to the development of a novel, first-in-class, anti-HIV-1 therapeutics. Kalpana laboratory is also investigating of mechanism of HIV-1 persistence using single-cell and single-molecule RNA-FISH and RNA-seq, and the role of INI1/SMARCB1 on HIV-1 transcriptional and post-transcriptional events. Currently, we are investigating host-virus interactions of HIV-1 and the mechanism of HIV persistence and latency. These studies are focused on the interaction between integrase and INI1/SMARCB1.

The individuals to be appointed will have the opportunity to lead exciting projects designed to unravel the molecular mechanisms of HIV/AIDS using molecular biology, biochemistry, virology, structural biology and cell biology approaches.

Note that NY state has one of the lowest COVID-19 positivity rates in the country!

Please email Dr. Ganjam V. Kalpana ganjam.kalpana@einsteinmed.org

Mark Trauner Faculty Scholar in Neuro-Oncology

Professor, Department of Genetics

Professor, Department of Microbiology and Immunology

Albert Einstein College of Medicine, New York 

https://einsteinmed.org/faculty/6576/ganjam-kalpana/