Deconvoluting host-gut microbiota co-metabolism

Seminar Details
Tuesday, April 26, 2022 - 4:00pm to 5:00pm


Pamela Chang
Assistant Professor, Cornell University


Zoom Meeting:

Meeting ID: 978 0533 3325

Passcode: 2022

LSA Chemistry Seminar

Speaker Profile 

Abstract: Despite the abundance and prevalence of the gut microbiota, little is known regarding the pathways and mechanisms by which these microbes affect host health. Emerging evidence suggests that many small molecule metabolites that are produced by the gut microbiota have the ability to modulate host defense mechanisms in various inflammatory diseases. We describe several amino acid-derived metabolites produced by the gut microbiota that improve morbidity in mouse models of inflammatory bowel disease (IBD) and gastrointestinal infection. In complementary work, we have also developed chemical approaches for probing the metabolic activities of biosynthetic enzymes expressed by the gut microbiota that are responsible for producing important classes of small-molecule metabolites whose metabolism is dysregulated in IBD.