Multi-omics phenome-wide association of DUOX2 variants identifies a potential plasma biomarker for mucosal dysbiosis

Seminar Details
Wednesday, May 8, 2019 - 9:00am to 10:00am


Helmut Grasberger, M.D.
Research Fellow, Division of Gastroenterology


5623 Med. Sci. II  (Wheeler Seminar Room)

John Kao, M.D.

Previous studies in mice showed that induction of H2O2-generating dual oxidase 2 (Duox2) in barrier epithelia constitutes a sentinel response to mucosal dysbiosis. In addition, Duox2-deficiency in mice alters mutualistic host-microbiota interactions that are fundamental in maintaining healthy gut immune homeostasis. Rare loss-of-function DUOX2 variants are commonly found in the general human population. We present evidence linking DUOX2 mutational burden with susceptibility to mucosal dysbiosis and associated phenotypes.