Universal Biology in Adaptation and Evolution: Multilevel Consistency, Dimensional Reduction, and Fluctuation-Response Relationship

Seminar Details
Tuesday, February 9, 2021 - 7:00pm to 8:30pm


Kunihiko Kaneko, PhD
Universal Biology Institute, University of Tokyo


Presented by the Center for the Study of Complex Systems

A macroscopic theory for cellular states with steady-growth is presented, based on consistency between cellular growth and molecular replication, as well as robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, from which a macroscopic law for cellular states is derived, as is confirmed by adaptation experiments of bacteria under stress. Next, the theory is extended to phenotypic evolution, leading to proportionality between phenotypic responses against genetic evolution and by environmental adaptation. Evolutionary relevance of slow modes in controlling high-dimensional phenotypes is discussed. Last, I will touch upon the origin of central dogma in molecular biology as symmetry breaking between function and information.