September 24, 2021
12:00 pm to 1:00 pm
Anh Huynh
Graduate Student, LSA Biophysics Graduate Program

Spatial heterogeneity can dramatically impact evolution in bacterial communities, raising the question of whether spatial profiles of drug concentration can be tuned to slow the emergence of antibiotic resistance. In this work, we combine lab evolution experiments in spatially connected, computer-controlled chemostats with mathematical models to investigate resistance evolution in E. faecalis, an opportunistic bacterial pathogen.

September 30, 2021
12:00 pm to 1:00 pm
Jonothan Golob, MD, Ph.D.
Assistant Professor, Department of Infectious Diseases, Michigan Medicine

Golob Lab

Computational Medicine and Bioinformatics, Tools & Technology Seminar Series

October 15, 2021
3:30 pm to 4:30 pm
Craig Bethke, Ph.D.
Professor Emeritus, University of Illinois at Urbana-Champaign

Geoscientists appreciate, if only from undergraduate textbooks, that functional groups of microbes in Earth’s subsurface arrange themselves into zones according to an energetic hierarchy, or a “thermodynamic ladder.” According to the theory of competitive exclusion, the functional group that derives the most chemical energy from its environment outcompetes other groups there, coming to overtake its habitat. We might observe sediments near an aquifer’s recharge populated by aerobes, followed downgradient by zones hosting iron-reducing bacteria, sulfate-reducers, and finally methanogens.

December 1, 2021
4:00 pm
Donnele Daley, MD
Assistant Professor of General Surgery, University of Michigan Medical Center

Molecular Integrative Physiology Seminar

Hosted By: Costas Lyssiotis