Inhaled oxygen is among our most commonly administered therapies, yet hyperoxia - elevated inspired oxygen - causes lethal lung injury in animals, and in humans is associated with increased mortality and severe lung disease. Our laboratory has recently discovered that the lung microbiome is altered by inhaled oxygen, contributing to the development of oxygen-induced lung injury. In this talk, I will discuss how we are determining the role of the lung microbiome in oxygen-induced lung injury by integrating observational human data with in vivo, in vitro, and ex vivo models.
