Gut translocation and lung injury in the ICU: mice, pigs, and people

Seminar Details
Wednesday, April 3, 2019 - 9:00am to 10:00am


Robert Dickson, M.D.
Assistant Professor
Pulmonary and Critical Care Medicine
Michigan Medicine


5623 Med. Sci. II  (Wheeler Seminar Room)

Sponsoring Department(s)

Our group has previously demonstrated that in critically ill patients, the lungs and other end-organs are enriched with gut-associated bacteria. This observation has re-ignited the "gut translocation hypothesis" of multi-organ failure: that in patients with shock, increased intestinal permeability results in dissemination of gut bacteria and bacterial products, contributing to the pathogenesis of multi-organ failure. In this talk, I will share recent observations exploring the mechanisms and significance of gut translocation in critical illness. I'll share translational findings from complementary mouse, pig, and human studies.