Refreshments served at 9:30 AM
Refreshments will be served at 8:15 AM
Peptidase-containing ABC transporters (PCATs) are a widely distributed family of transporters which export peptide substrates containing a double-glycine motif (GG peptides). In gram-positive bacteria, PCATs secrete pheromones used for cell-to-cell signaling and antimicrobial peptides called bacteriocins used for interbacterial killing and competition. PCATs recognize GG peptides through their N-terminal signal sequences, but little is known about how PCATs distinguish between different GG peptides.
For Monday, Jay Vornhagen Ph.D. from the Bachman lab will lead our last but not least BPJC discussion before summer:
See downloads (2) below
Presenter for Monday, April 8th: Matthew Ostrowski, Ph.D. (Research Fellow, Martens Lab)
On Monday Matt Ostrowski from the Martens lab will discuss a recent Cell Host Microbe paper illustrating the model of bacterial commensals influencing the dissemination/spread of disease.
See download (below)
Presenter for Monday, March 25th, 2019: Ed Ong (Oliver He lab)
Victors: a web-based knowledge base of virulence factors in human and animal pathogens
See Link (below)
Our group has previously demonstrated that in critically ill patients, the lungs and other end-organs are enriched with gut-associated bacteria. This observation has re-ignited the "gut translocation hypothesis" of multi-organ failure: that in patients with shock, increased intestinal permeability results in dissemination of gut bacteria and bacterial products, contributing to the pathogenesis of multi-organ failure. In this talk, I will share recent observations exploring the mechanisms and significance of gut translocation in critical illness.