Microbiology & Immunology

Dissertation Seminar - Regulation and Substrate Selectivity of Peptide Exporters and Their Functional Significance in Streptococcus pneumoniae

Thursday, August 15, 2019 - 2:00pm to 3:00pm
Charles Wang
MSTP graduate student (Dawid Lab)
Department of Microbiology and Immunology
University of Michigan

Peptidase-containing ABC transporters (PCATs) are a widely distributed family of transporters which export peptide substrates containing a double-glycine motif (GG peptides). In gram-positive bacteria, PCATs secrete pheromones used for cell-to-cell signaling and antimicrobial peptides called bacteriocins used for interbacterial killing and competition. PCATs recognize GG peptides through their N-terminal signal sequences, but little is known about how PCATs distinguish between different GG peptides.

Bacterial Pathogenesis Journal Club

Monday, April 8, 2019 - 10:00am to 11:00am

Presenter for Monday, April 8th: Matthew Ostrowski, Ph.D. (Research Fellow, Martens Lab)

On Monday Matt Ostrowski from the Martens lab will discuss a recent Cell Host Microbe paper illustrating the model of bacterial commensals influencing the dissemination/spread of disease.

See download (below)

Gut translocation and lung injury in the ICU: mice, pigs, and people

Wednesday, April 3, 2019 - 9:00am to 10:00am
Robert Dickson, M.D.
Assistant Professor
Pulmonary and Critical Care Medicine
Michigan Medicine

Our group has previously demonstrated that in critically ill patients, the lungs and other end-organs are enriched with gut-associated bacteria. This observation has re-ignited the "gut translocation hypothesis" of multi-organ failure: that in patients with shock, increased intestinal permeability results in dissemination of gut bacteria and bacterial products, contributing to the pathogenesis of multi-organ failure. In this talk, I will share recent observations exploring the mechanisms and significance of gut translocation in critical illness.